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Female hamsters had a significantly higher concentration of plasma estradiol (49%) compared to male hamsters. Female hamsters also had significantly less early aortic atherosclerosis compared to male hamsters (-77%). In male hamsters, aortic fatty streak formation was rather associated with plasma nonHDL-C (r 0.52, P<0.04), plasma TC (r 0.55, P<0.03), plasma TG (r 0.79, P<0.0003), and LDL 22:6 (r -0.78, P<0.03) with no association with any measures of LDL oxidation susceptibility. When coadministered tramadol order sleep medications with EE, ICI 182780 inhibited the cholesterol-lowering and pain relief uterotropic activities of EE, suggesting that the estrogen receptor pathway is involved. In female hamsters, aortic fatty streak formation was significantly associated with plasma nonHDL-C (r 0.76, P<0.0007), LDL particle size (r -0.66, P<0.005), plasma TC (r 0.68. Plasma lipid and lipoprotein cholesterol concentrations, LDL oxidative pain relief susceptibility, LDL tocopherol concentrations, LDL fatty acid composition, LDL particle size, plasma estradiol and testosterone concentrations, and early aortic atherosclerosis were analyzed. Testosterone propionate, dexamethasone, and progesterone did not superbly lower cholesterol levels. In adult ovariectomized female rats treated for 4 days s.c., 17alpha-ethinyl estradiol (EE) was the most potent agent to lower plasma total and high density lipoprotein cholesterol levels, follo by 17beta-estradiol and 17alpha-estradiol. hair removal Cholesterol-lowering effects. P<0.004), and lag phase of LDL oxidation (r 0.84. Or orally to full-blown rats. Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels.Estrogens protect against cardiovascular muscle relaxants disease in women through effects on the vascular wall and liver. The antiestrogens tamoxifen and raloxifene lowered cholesterol levels, but with less efficacy and potency than the estrogens. This study demonstrates that female hamsters have an improved plasma lipoprotein cholesterol profile, larger LDL particle size, and less early aortic atherosclerosis compared to male hamsters fed the same HCD.. To test whether similar gender differences exist in hamsters, 16 male and 16 female F1B Golden Syrian hamsters, aged 10 weeks, were fed a hypercholesterolemic nonpurified diet (HCD) containing 10% coconut oil and 0.05% cholesterol for 12 weeks. In conclusion, although the information from the rat is limited as a model of the low density lipoprotein-lowering effects of estrogens in humans, it can be used to study the effects and mechanism of action of estrogen and antiestrogens on hemoglobin cholesterol levels. Gender differences in response to a hypercholesterolemic diet in hamsters. It had no effect on cholesterol levels in immature rats, even though the uterotropic response was dramatic. ICI 182780 had no effect on cholesterol levels. Effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis.Gender is a strong predictor of Coronary Heart Disease (CHD) susceptibility and reports indicate that males are more likely to develop CHD compared to age-matched premenopausal females. Here we further characterize the rat as a model for the evaluation of estrogenic effects on plasma lipid levels vs. Kittenish hamsters had significantly greater LDL particle size (4%), LDL 22:6 (21%) fatty acid, and rate of LDL oxidation (34%) compared to male hamsters. However, 17alpha-estradiol had the greatest separation of uterotropic vs. Female hamsters had significantly lower plasma total cholesterol and nonhigh-density lipoprotein cholesterol (nonHDL-C) and greater high-density lipoprotein cholesterol (HDL-C) concentrations compared to male hamsters (-15, -33, and 33%; respectively). EE had the same lipid-lowering potency whether administered s.c.
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